Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity which includes dermatophytes, yeasts and moulds in women by inserting the Pessaries high into the vagina using the applicator. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes.
Presentation
Blister Pack of 1×6 Pessaries with applicator.
Composition
Each Pessary Contains:
Clotrimazole BP 100 mg
Excipients Q.S.
Indications
For the treatment of vaginal thrush (candidiasis).
Pharmacological class
Antifungal
Pharmacological properties
Fungicidal
Mechanism of action
Clotrimazole exerts its effect by altering the fungal cell membrane. Clotrimazole inhibits ergosterol synthesis by interacting with 14-alpha demethylase, a cytochrome P-450 enzyme that is necessary for converting lanosterol to ergosterol, an essential component of the membrane.
Contraindications
There are no known contraindications to use of Renesten V Pessaries, except Hypersensitivity to any of the ingredients.
SPECIAL PRECAUTIONS FOR STORAGE
Store in a dry and dark place, between 15° C-30°C.
Keep out of reach of children. Do not swallow.
